KMID : 0367320050160020183
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Journal of the Korean Academy of Child and Adolescent Psychiatry 2005 Volume.16 No. 2 p.183 ~ p.191
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TIC DISORDER AND OBSESSIVE COMPULSIVE DISORDER IN CHILDHOOD
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Hong Hyun-Ju
Song Dong-Ho
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Abstract
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Tic disorder including Tourette¡¯¡¯s disorder is a neurodevelopmental disorder that appears in childhood and characterized by the presence of motor and vocal tics. Childhood-onset obsessive-compulsive disorder (OCD) is suggested to be a phenomenologically and etiologically distinct subtype of OCD, bearing a close genetic relationship to tic-disorders. Tourette¡¯¡¯s disorder and OCD are comorbid in 40-75% of patients initially diagnosed with either disorder. Basal ganglia and cortico-striato-thalamic circuits are implicated in the pathophysiology of both disorders and these disorders have similar clinical features. Over the past decades, the progress in research on Tourette¡¯¡¯s disorder and OCD has been extraordinary. This review describes some of important insights from these work, involving these areas : 1) clinical implication 2) genetics and epidemiology 3) brain imaging study 4) neuroche-mistry 5) pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS).
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KEYWORD
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Tic/Tourette¡¯s disorder, Obsessive-compulsive disorder, Childhood
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